City have been linked regularly with the Portuguese midfielder, who has been one of the stars of Wolves' impressive first season back in the Premier League.
"I didn't speak with him so that one time I can not say what he thinks because I don't know".
Guardiola tried to sign Jorginho from Napoli to fulfil that role last summer but the player opted to join Chelsea instead.
City have Sergio Aguero in contention for Monday's game after he returned to training following flu, while Vincent Kompany is fighting to be fit to face Wolves.
The former Barcelona and Bayern Munich boss added: "Specifically with Fernandinho's role, it's so hard to find. He'll be 34 and he can not play every few days".
"The system at Wolves involves playing with two holding midfielders, not just one". That is not going to happen.
And while Pochettino has somewhat managed to find adequate cover in the holding midfield role, Spurs have struggled to provide creativity without the services of Christian Eriksen, especially with Dele Alli not exerting the same dominance as before.
Guardiola did not reference De Jong but conceded City face a hard task beating Barca and Madrid when it comes to transfers.
"You have to pay the club, pay the family and talk with the players, and with the agents, it's nuts".
But with City still fighting for silverware on four fronts, the Catalan is happy to rely on John Stones and Ilkay Gundogan until the end of the season. The German at least looked comfortable in the position as Fernandinho was rested for the cup thrashings of Rotherham and Burton over the past week, which City won by a combined scoreline of 16-0. He has the quality and the vision to pass. "He's a fantastic player".
Guardiola, who is in his third season as City manager, is interested in signing Ajax's Frenkie De Jong, according to reports.
"We realised that last season in Carabao Cup, we saw how complicated they are", he said.