John Millman stuns Roger Federer in four sets at U.S. Open

Novak Djokovic takes charge against Richard Gasquet in Round 3

Sousa arrived at the season's final Grand Slam in terrible form having lost his last seven matches but suddenly found his game on the Flushing Meadows hardcourts knocking off two seeded players, number 12 Pablo Carreno Busta and number 17 Lucas Pouille, on route to the last 16.

Djokovic fulfilled his role in setting up the mouthwatering last eight clash by beating Joao Sousa 6-3 6-4 6-3.

Madison Keys had to work on Labor Day, but not too hard, cruising into the US Open quarterfinals - two wins shy of matching her finals appearance previous year.

Djokovic, however, said he wasn't counting on 44th-ranked Sousa, who advanced past 12th seed Pablo Carreno Busta and No. 17 Lucas Pouille, going quietly.

Should Federer get through against the 55th-ranked Australian, he'll set up his earliest Grand Slam meeting with Djokovic since 2007, when Federer beat Djokovic to reach the Australian Open quarter-finals.

The 32 degree celsius heat, though, is much tougher on Djokovic, who showed the same blank expression, rosy cheeks and sweat-soaked shirt as during his first-round match last week. A hold at love moved Nadal 3-1 in front and he grabbed another break in game five when Djokovic netted another routine shot from his right wing that let him down completely. Credit to Joao for fighting, he brought a lot of intensity on the court.

Nishikori was glad he didn't need more than three sets in the blazing sunshine on Louis Armstrong Stadium.

"It was nearly unreal", Kyrgios reportedly said after the match, adding: "If anyone else is doing those shots against me, I'm probably not too happy".

But on the very same court on which Federer destroyed Hewitt 6-0 7-6 6-0 in the 2004 US Open final, Millman stared down the greatest player of the professional era to send the world No.2 crashing to his earliest grand slam defeat in nearly four years.

"Man, really lucky to finish in three sets", Nishikori said.

No. 14 seed Madison Keys remains in the hunt for her first Grand Slam title a year after making the US Open final.

Seventh-seeded Cilic, who needed eight match points in a five-set marathon against Australian teenager Alex de Minaur spilled into Sunday morning survived some tense moments to get past 10th-ranked Belgian David Goffin 7-6 (8/6), 6-2, 6-4.

Kohlschreiber was denied again in his fifth attempt to win a fourth-round match at the US Open.

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