Cilic misses US Open chance as Schwartzman progresses

US Open Tennis 2017 Schedule: Replay TV Coverage, Live Stream for Friday's Draw

"I had some good memories from a year ago, so of course I want to go as far as possible, and I want to take any opportunities", Pouille said. Many players are injured this week.

Schwartzman, who next meets 16th seed Lucas Pouille, is happy to be an inspiration for smaller players.

"I just worry about the next match and the next match and the next match", Muguruza said. I struggle playing at night at this tournament. "I try to improve every week and I'm really happy". John Isner is the best remaining seed, but Cilic's loss allows basically any remaining player in the bottom half to envision a realistic path to the semifinal.

Elsewhere, Britain's hopes were ended after Kyle Edmund was forced to retire against Canadian Denis Shapovalov after picking up a neck injury during the third set.

"Kind of a freak year with all these injuries", said Querrey, 29, who has never made it past the fourth round of the Open. "Hopefully it's nothing too serious".

The result means that Simona Halep and Venus Williams have both been eliminated from contention for the world number one ranking, with Muguruza, Karolina Pliskova and Elina Svitolina the only ones still left with a chance to leave NY as the world's top-ranked female tennis player.

Pablo Carreno Busta, of Spain, returns a shot from Nicolas Mahut, of France, during the third round of the U.S. Open tennis tournament, Friday, Sept. 1, 2017, in NY.

Garbine Muguruza will have her eyes set on the U.S. Open crown in NY after seeing some of the women's favourites drop out early, and she will face Magdalena Rybarikova for a fourth-round spot on Friday.

The teenager is the youngest man to reach the fourth round of a grand slam in almost 20 years and looks to be heading quickly for the top of the game.

"Obviously I'm super-excited", United States ninth seed Venus said.

Two-time Wimbledon champion Petra Kvitova moved into the U.S. Open's fourth round with a 6-0, 6-4 victory over 18th-seeded Caroline Garcia of France. "Words can't describe" during a pre-match interview with the host broadcaster, ESPN. Every time in the third set, as well.

Kvitova, the 2011 and 2014 Wimbledon champion, enjoyed playing in Arthur Ashe Stadium after needing major left hand surgery following a knife attack by a home intruder last December. For players like Isner and Querrey, it's the opportunity of a lifetime-a plausible road to the final of the U.S. Open, with no obvious insurmountable challenge in their way.

Two of the others, current No. 1 Karolina Pliskova and Elina Svitolina, will play Saturday.

She eliminated Venus Williams and already ousted second-ranked Simona Halep from the top spot chase. Milos Raonic, ranked 11th, also pulled out of the U.S. Open before it began. The 26-year-old Spaniard delivered his best Grand Slam result on clay - the quarter-finals of Roland Garros in June.

It was a landmark victory for Schwartzman, one of the smallest men on the tour at 5ft 7in, who is through to the fourth round at a slam for the first time.

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