Her goal of getting a career Grand Slam will have to wait, and it's now in jeopardy.
"I'm really happy for her and I'm glad to see all of the players giving her a warm welcome back because she deserves it and she's such a great champion and a truly wonderful person off the court that she deserves that and more", said Rio Olympic gold medalist Monica Puig.
The two-time Wimbledon champion's comeback at the French Open ended in the second round Wednesday in a close match against qualifier Bethanie Mattek-Sands, who recorded her best result at a major in almost two years with a 7-6 (7-5), 7-6 (7-5) victory. She takes the match 6-2, 6-2.
Makarova's show on Philippe-Chatrier Court sends the former world No.8 into a second-round meeting with one of two Ukrainians - Lesia Tsurenko or Kateryna Kozlova.
Although maybe not, considering how Kerber has fared lately.
That picture offers the starkest of contrasts with a spectacular 2016 that also brought her major wins in the Australian and US Opens and a runner-up spot at Wimbledon. Makarova pointed out she never had played a singles match in the tournament's main stadium (she was the 2013 French Open women's doubles champion).
Kerber struggled with 25 unforced errors against just 16 winners, and won less than 50 percent of points behind her first serve.
Having won an emotional opening-round match against Julia Boserup, Kvitova had her chances against another American, 32-year-old Mattek-Sands, who had come through qualifying.
"She's one of the nicest girls, and we are all really happy to see her back".
The 27-year-old Kvitova, who is seeded 15th, hit nine aces and broke her opponent's serve three times. Gave her a big hug. "She not only came back from all of that, she came back playing well".
If you don't like long lines that move nowhere for what seems like an eternity, then we recommend you get to the French Open early - and by early we mean before the early bird catches the worm.
On the men's side, defending champion and second-seeded Novak Djokovic advanced by beating Joao Sousa, 6-1, 6-4, 6-3.
Kvitova had initially targeted Wimbledon, where she won the title twice in 2011 and 2014, for her comeback but she progressed faster and, therefore, chose to head to Paris.
Tsonga had never lost to a player ranked as low as No. 91 at a Grand Slam.
The German, who also lost in round one past year, has had a miserable season and is not a fan of clay so the result came as no real surprise.
Murray Downs Del Potro in blockbuster match
She played her typically safe style for much of the match, winding up with 15 fewer unforced errors than No. 8 Kuznetsova. I knew that if I stayed behind the baseline, he can only do so much. "So I like to play chess in my free time".
GOP health bill a far cry from Trump promises
The CBO report did find that over time premiums would come down under the House bill, even if more people become uninsured. A review of the CBO's Obamacare projections reveals how flawed their prediction models on health care have been.