Clayton Richard held the Milwaukee Brewers to one run over five of his innings Tuesday at Petco Park.
The Brewers took a 5-4 lead in the top of the 10th on Eric Sogard's homer with one out against Jose Torres (2-2).
Jhoulys Chacin (4-3, 5.12 ERA) will start for San Diego on Wednesday.
"It's big to be leading 5-0 before you throw a pitch". I hit it on a line. The pitch just got too much of the plate, and he got it. "I'm definitely just grateful to be out there after missing previous year".
The first walk-off homer of Renfroe's career capped a resurgence for the power hitter whose batting average dropped to.200 on May 9. He threw two innings of one-run ball.
"Daddy hit his home run and then the Padres hit a home run", Kaycee explained. "As he started to shrink the zone, pitchers started coming back toward it and then he drives balls in the gap and drives runs in".
"I knew I hit it pretty well", Renfroe said. We are the only station in Milwaukee to provide the latest news, weather and sports on the device.
Sogard's four hits are a career high.
"It would have been nice to get the win", Sogard said. "But sometimes for me as a pitcher, it mentally helps to not get comfortable and pitch like it is a 0-0 game. go out there with a 0-0 mentality so you don't get complacent".
"I'm having fun just being part of this team", said Sogard, who missed the entire 2016 season because of a knee injury.
That blew what would have been San Diego starter Luis Perdomo's first win of the season.
Nelson pitched almost seven innings of two-run ball, striking out eight and holding the Padres scoreless through the fifth inning for his second win of the year. Aguilar and Santana drove in the runs.
Austin Hedges started the rally by drawing a one-out walk from Brewers starter Chase Anderson.
The Padres scored their second run when Hunter Renfroe and Matt Szczur opened the seventh with back-to-back doubles off Nelson.
Perdomo's two-out triple to centre in the second gave the Padres a 3-0 lead.
The Brewers jumped out early, scoring five runs in the first inning. Perez scored the tying run on Domingo Santana's RBI single to right with one out. However, Perdomo struck out Nick Franklin and induced Jett Bandy to ground into an inning-ending double play.
Josh Reddick doubled in the sixth off Junichi Tazawa (1-1), and after a walk and a hit batter loaded the bases, Gurriel connected with two outs for a 4-1 lead. The Brewers countered in the sixth on Aguilar's two-out solo homer off Perdomo.
The Brewers tied it at 4 in the eighth.
Padres: Green said a CT scan revealed LF Travis Jankowski has a fracture in his left foot and he'll be out an additional six weeks. Jankowski has been out since April 23 with what was originally diagnosed as a bone bruise. He had missed Monday's series opener with what was described as a combination of the flu and sore legs. The Brewers recalled LHP Brent Suter from Triple-A Colorado Springs on Monday and designated RHP Jhan Marinez for assignment.
San Francisco opened the inning with three straight hits off McCarthy (3-1), with an RBI double by Brandon Crawford putting the Giants up 2-1.