Casemiro's stunning volley crowned a superb display from Real Madrid, who fought back to beat Napoli 3-1 at the Bernabeu in the first leg of their Champions League last 16 tie on Wednesday.
Karim Benzema levelled the scores before half time and the holders carried the momentum into the second half as Toni Kroos and Casemiro added further goals to strengthen their grip on a place in the quarter-finals.
Madrid promptly responded and should've equalised through Benzema, who was picked out by Ronaldo in Napoli's penalty area but - despite being directly in front of Reina's goal - couldn't guide his header on target.
There was hardly time to take a breath in the opening five minutes of action as Real Madrid continued to force the issue, but Napoli were a danger when they had the chance to counter through Callejon, Dries Mertens and Insigne.
Napoli will test the durability of Real Madrid's European fortress.
Real Madrid with the loss of goal scoring form from Cristiano Ronaldo, who has gone nearly five games without a goal in the competition, will look to French striker Karim Benzema who has scored four of Real Madrid's last six Champions League goals and will be hoping to add to his career total of 53 in the competition.
The 23-year-old has become a vital part of the Madrid midfield this season after originally having to grow his game on-loan at Porto. And, prior to the game, fans held aloft a mosaic with a message that read: "Together, we are unstoppable".
The frantic pace of the match had evaporated in the closing 10 minutes, with both teams suffering with fatigue and mental tiredness.
The hosts, meanwhile, boast the top scorer in the history of the competition, and Cristiano Ronaldo is offered at 8/15 (1.53) to continue his impressive run of scoring in the last 16 of the Champions League. Moreover, Coach Zidane also wants his team to take every opportunity that they can get while in the game. They're small, tricky players with good technique.